Having two paths to get methyl groups into pool is like having a fail-safe system. Everything works together like a well-oiled machine, and in optimal circumstances, both TMG and DMG efficiently pump methyl groups into the methyl pool to produce SAM-e (S-Adenosyl methionine) from homocysteine. ![]() TMG transfers its methyl group directly to homocysteine, while DMG uses the folic acid (methylfolate) pathway. ![]() Both TMG and DMG are integral parts of the one-carbon cycle, and they both play critical roles in methylation pathways.* Proper methylation is essential for DNA replication and repair, energy production, immune response, stress support, and glutathione recycling.* Glutathione (the chief free radical fighter and detoxifier) is of particular importance, as without well-functioning methylation, the body doesn't produce glutathione.
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